Spravato

What is Spravato® and how does it work?

Spravato® is an FDA-approved nasal spray used to treat adults with treatment-resistant depression. It contains esketamine, a ketamine-derived medication, and works differently from traditional antidepressants.

Rather than primarily targeting serotonin or norepinephrine, Spravato acts on NMDA receptors in the brain. This unique mechanism may help support new neural connections and improve symptoms of depression in individuals who have not responded adequately to other treatments.

Because of the way it works, Spravato offers an alternative treatment option for some adults living with treatment-resistant depression.

Who may be a candidate for Spravato treatment?

Spravato is generally recommended for adults diagnosed with major depressive disorder (MDD) who have not experienced sufficient improvement after trying at least two antidepressant medications.

A qualified provider at 180 Mental Health and Wellness performs a comprehensive evaluation to determine whether Spravato is appropriate for your needs and medical history.

Spravato may be considered for individuals with:

• Major depressive disorder (MDD)
• Treatment-resistant depression
• Persistent depressive symptoms despite previous treatment

Treatment recommendations are individualized based on your symptoms, treatment history, and overall mental health needs.

What should I expect during a Spravato appointment?

Spravato is administered at 180 Mental Health and Wellness under medical supervision as required by the FDA Risk Evaluation and Mitigation Strategy (REMS) program.

After self-administering the nasal spray, you remain in the office for observation while the clinical team monitors your response and helps ensure your safety. During this time, your vital signs may be checked, and you can rest comfortably while the medication takes effect.

Some patients experience temporary side effects such as dizziness, drowsiness, nausea, increased blood pressure, or dissociation. Because of these effects, you will need transportation home following your appointment and should not drive until the next day after a full night's sleep.

How quickly can Spravato help improve depression symptoms?

One of the distinguishing features of Spravato is its potential to work more quickly than many traditional antidepressants. While individual responses vary, some patients may notice symptom improvement within days of starting treatment.

Regular follow-up visits help the team monitor your progress, evaluate your response to treatment, and make recommendations as needed.

At 180 Mental Health and Wellness, Spravato treatment is provided as part of a personalized medication management plan designed to help address treatment-resistant depression safely and effectively.

Call the office or schedule an appointment online today to learn whether Spravato may be right for you.